Journal
ENGINEERING IN LIFE SCIENCES
Volume 14, Issue 5, Pages 456-466Publisher
WILEY
DOI: 10.1002/elsc.201300075
Keywords
Bioinformatics; Functional genomics; Metabolic engineering; Plant biology; Secondary metabolism
Categories
Funding
- Natural Science Foundation of China [81373908]
- Zhejiang Provincial Natural Science Foundation of China [LQ13C020003, Y3090487]
- Science Foundation of Zhejiang Sci-Tech University [1204806-Y, 1204822-Y]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201326902]
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Plant secondary metabolites play an important role in the fields of food, medicine, agriculture, and biofuels. Secondary metabolites are an important focus of crop breeding and metabolic engineering research. However, our understanding of secondary metabolism is far from complete, particularly in nonmodel plants. Functional genomics, which includes transcriptomics, proteomics, and metabolomics, opens a new avenue for deciphering secondary metabolism. Here we review the applications of functional genomics in secondary metabolism, including the discovery of novel genes, the identification of gene function, and the detection of novel pathways of the metabolic network. Results from these studies will accelerate our understanding of elicitation mechanism of secondary metabolism and how plants interact with their environment, ultimately improving the production of secondary metabolites by means of metabolic engineering.
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