Journal
ENGINEERING IN LIFE SCIENCES
Volume 13, Issue 6, Pages 549-562Publisher
WILEY
DOI: 10.1002/elsc.201300021
Keywords
Biopolymers; Cell lysis; Downstream processing; Extraction solvents; Polyhy-droxyalkanoates
Categories
Funding
- European Commission
- Acronym ANIMPOL [245084]
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To provide competitive alternatives to classical plastics, production of poly[(R)-3-hydroxyalkanoate] (PHA) biopolyesters has to become more economical. Downstream processing for PHA recovery from biomass plays a vital role in the PHA manufacturing process with respect to cost performance, material quality, and eco-balance. Several factors impact the selection of the adequate PHA recovery method: the microbial production strain, type and composition of PHA, PHA load in biomass, required product purity, availability of chemicals for PHA recovery, and impact on physical properties of PHA. In this review, we compare classical and novel strategies for PHA recovery from microbial biomass. Approaches for reducing solvent and energy inputs, focusing on obtaining endotoxin-poor PHA for medical application, are presented, as well as recent developments in efficient disruption of PHA-rich biomass. In addition, particularities of extremophiles and genetically modified microorganisms with properties facilitating the release and separation of PHA granules are discussed.
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