Journal
ENGINEERING IN LIFE SCIENCES
Volume 10, Issue 5, Pages 398-406Publisher
WILEY
DOI: 10.1002/elsc.201000011
Keywords
Bacillus subtilis; Biofuels; Cellulase expression; Consolidated bioprocessing; Metabolic engineering
Categories
Funding
- DOE BioEnergy Science Center
- Office of Biological and Environmental Research in the DOE Office of Science
- USDA Bioprocessing and Biodesign Center
- DuPont Young Professor Award
Ask authors/readers for more resources
One-step consolidated bioprocessing that integrates cellulase production, cellulose hydrolysis, and product fermentation into a single step for decreasing costly cellulase use, increasing volumetric productivity, and reducing capital investment is widely accepted for low-cost production of biofuels or other value-added biochemicals. Considering the narrow margins between biomass and low-value biocommodities, good physiological performance of industrial microbes is crucial for economically viable production. Bacillus subtilis, the best-characterized Gram-positive microorganism, is a major industrial microorganism with numerous valuable features such as hexose and pentose utilization, low-nutrient needs, fast growth rate, high protein secretion capacity, industrial safety, etc. As compared with other potential consolidated bioprocessing microorganisms such as Clostridium spp., Escherichia coli, and the yeast Saccharomyces cerevisiae, recombinant cellulolytic B. subtilis strains would be a potential platform for biocommodity production from nonfood biomass. Here, we review the advances in recombinant cellulolytic B. subtilis development and metabolic engineering for biocommodity production, and discuss the opportunities and challenges of cellulolytic B. subtilis for biocommodity production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available