Journal
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Volume 19, Issue 1-3, Pages 109-134Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1088424615300037
Keywords
photodynamic therapy; nanoparticles; nanoplatforms; cancer-imaging; multimodality agents; theranostics; fluorescence; nuclear imaging; magnetic resonance imaging
Categories
Funding
- NIH [CA119358, PO1 CA55791, RO1 CA127369, R21 CA176154]
- Photolitec, LLC, Roswell Park Alliance
- NCI Cancer Support Grant [CA016156]
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This review article briefly describes: (a) the advantages in developing multifunctional nanoparticles for cancer-imaging and therapy, (b) the advantages and limitations of most of the porphyrin-based compounds in fluorescence imaging and photodynamic therapy (PDT), (c) problems associated with current Food and Drug Administration (FDA) approved photosensitizers, (d) challenges in developing in vivo target-specific PDT agents, (e) development of porphyrin-based nuclear-imaging agents (PET, SPECT) with an option of PDT, (f) the importance of light dosimetry in PDT, (g) the role of whole body or local hyperthermia in enhancing tumor-uptake, tumor-imaging and phototherapy and finally, (h) the advantages of photosensitizer-gold nanocages (Ps-Au NC) in photoacoustic and PDT.
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