Journal
ACS NANO
Volume 9, Issue 6, Pages 5913-5921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b00532
Keywords
gadolinium neutron capture therapy; calcium phosphate micelle; drug delivery system; MRI
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Funding
- Center of Innovation Program (COI stream from Japan Science and Technology Agency (JST)
- Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST) from the Japan Society for the Promotion of Science (JSPS)
- JSPS [P13042]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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Gadolinium (Gd) chelates-loaded nanocarriers have high potential for achieving magnetic resonance imaging (MRI)guided Gd neutron capture therapy (GdNCT) of tumors. Herein, we developed calcium phosphate micelles hybridized with PEG-polyanion block copolymers, and incorporated with the clinical MRI contrast agent Gd-diethylenetriaminepentaacetic acid (Gd-DTPA/CaP). The Gd-DTPA/CaP were nontoxic to cancer cells at the concentration of 100 mu M based on Gd-DTPA, while over 50% of the cancer cells were killed by thermal neutron irradiation at this concentration. Moreover, the Gd-DTPA/CaP showed a dramatically increased accumulation of Gd-DTPA in tumors, leading to the selective contrast enhancement of tumor tissues for precise tumor location by MRI. The enhanced tumor-to-blood distribution ratio of Gd-DTPA/CaP resulted in the effective suppression of tumor growth without loss of body weight, indicating the potential of Gd-DTPA/CaP for safe cancer treatment.
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