Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 53, Issue 15, Pages 1785-1793Publisher
WILEY-BLACKWELL
DOI: 10.1002/pola.27621
Keywords
conjugated polymer; N-carboxyanhydride; poly-l-lysine; poly(ethylene glycol); poly(p-phenylene)s; polypeptide; ring-opening polymerization; Suzuki coupling; biopolymers; peptides; water-soluble polymers
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We report a novel approach for fabrication of multifunctional conjugated polymers, namely poly(p-phenylene)s (PPPs) possessing polypeptide (poly-l-lysine, PLL) and hydrophilic poly(ethylene glycol) (PEG) side chains. The approach is comprised of the combination of Suzuki coupling and in situ N-carboxyanhydride (NCA) ring-opening polymerization (ROP) processes. First, polypeptide macromonomer was prepared by ROP of the corresponding NCA precursor using (2,5-dibromophenyl)methanamine as an initiator. Suzuki coupling reaction of the obtained polypeptide and PEG macromonomers both having dibromobenzene end functionality using 1,4-benzenediboronic acid as the coupling partner in the presence of palladium catalyst gave the desired polymer. A different sequence of the same procedure was also employed to yield polymer with essentially identical structure. In the reverse sequence mode, low molar mass monomer (2,5-dibromophenyl)methanamine, and PEG macromonomer were coupled with 1,4-benzenediboronic acid in a similar way followed by ROP of the L-Lysine NCA precursor through the primary amino groups of the resulting polyphenylene. (c) 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1785-1793
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