Journal
JOURNAL OF POLYMER RESEARCH
Volume 22, Issue 8, Pages -Publisher
SPRINGER
DOI: 10.1007/s10965-015-0799-y
Keywords
Drug delivery systems; Stimuli-sensitive polymers; pH-sensitive nanoparticles; PEGylated sodium alginate; MCM-41 mesoporous silica
Categories
Ask authors/readers for more resources
In this study synthesis of a drug delivery system (DDS) is described which has several merits over its counterparts. In order to synthesize this nano-carrier, graphene oxide nano-sheets are used to accommodate MCM-41 nanoparticles. Furthermore Fe3O4 nanoparticles are introduced to this nanomaterial to produce a traceable nanoparticle. Since cancerous tissues have lower pH than healthy tissues, pH-sensitive oligomers are attached to this nano-material. Finally the nano-carrier is wrapped by a biocompatible shell (PEGylated sodium alginate); this polymeric shell makes the DDS capable of a more controllable drug release. Bymeasuring in vitro situation, 'loading content%' and 'entrapment efficiency%' proves to be 21 and 93.5 % respectively. In an acidic medium, the drug carrier without a polymeric shell (naked DDS) releases the whole of its drug content in 18 h, while the drug carrier with a polymeric shell (core-shell DDS) releases 45 % of its drug content during 48 h.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available