Journal
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
Volume 47, Issue 3, Pages 577-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2018.04.009
Keywords
Zollinger-Ellison syndrome; Gastrinoma; Neuroendocrine tumor; Acid secretion; Proton pump inhibitors; Multiple endocrine neoplasia type 1
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Funding
- Intramural NIH HHS [Z99 DK999999, ZIA DK053200-26] Funding Source: Medline
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This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present and also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial.
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