Journal
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
Volume 39, Issue 2, Pages 271-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2010.02.012
Keywords
Vitamin D; 25-Hydroxyvitamin D; 1,25-Dihydroxyvitamin D; Calcidiol; Calcitriol
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Funding
- NICHD NIH HHS [R01 HD047511-04, R01 HD047511] Funding Source: Medline
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The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (LA) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D-2 is much less bioactive than vitamin D-3 in humans. Metabolic activation and inactivation of vitamin D are well characterized and result in a plethora of metabolites, of which only 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) provide any clinically relevant information. 25(OH)D-2 and 25(OH)D-3 are commonly known as calcifediol and the 1,25(OH)(2)D metabolites as calcitriol. In this review the current state of the science on the clinical assessment of circulating 25(OH)D and 1,25(OH)(2)D is described.
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