Journal
ENDOCRINOLOGY
Volume 153, Issue 9, Pages 4412-4421Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2012-1416
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Funding
- Swedish Medical Research Council
- Karolinska Institutet
- Karolinska Funding for Doctoral Studies
- Tysta Skolan
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Estrogens' effects on hearing are documented across species, but the responsible molecular mechanisms remain unknown. The presence of estrogen receptors (ER) throughout the auditory system offers a potential pathway of direct estrogenic effects on auditory function, but little is known about how each ER's expression is regulated by the overall hormonal status of the body. In the present study, we determined the effects of ovariectomy and chronic 17 beta-estradiol treatment on mRNA and protein expression of ER alpha and ER beta in peripheral (cochlea) and central (inferior colliculus) auditory structures of mice, as well as on auditory-related behavior using the acoustic startle response (ASR), prepulse inhibition (PPI), and habituation of the startle response. 17 beta-Estradiol treatment down-regulated ER alpha but not ER beta and increased PPI and latency of the ASR. Neither the magnitude nor the habituation of ASR was affected. Furthermore, ER's mRNA and protein expression in the inner ear were analyzed throughout the estrous cycle (proestrus, estrus, metestrus, and diestrus), revealing a negative correlation of circulating estrogens with ER alpha expression, whereas ER beta was stable. Our findings show that ER not only are present in both the peripheral and central auditory system but also that circulating estrogen levels down-regulate ER alpha expression in the auditory system and affect PPI and the latency of ASR, suggesting a key role of ER alpha as a hormone-induced modulator of the auditory system and behavior. (Endocrinology 153: 4412-4421, 2012)
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