Journal
ENDOCRINOLOGY
Volume 152, Issue 4, Pages 1199-1208Publisher
OXFORD UNIV PRESS INC
DOI: 10.1210/en.2010-1041
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Funding
- National Institute of Child Health and Human Development
- Office of Research on Women's Health [R01HD047603]
- Helping Hands of Los Angeles, Inc.
- Johnson and Johnson
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The forkhead transcription factor (FOXL2) is an essential transcription factor in the ovary. It is important in ovarian development and a key factor in female sex determination. In addition, FOXL2 plays a significant role in the postnatal ovary and follicle maintenance. The diverse transcriptional activities of FOXL2 are likely attributable to posttranslational modifications and binding to other key proteins involved in granulosa cell function. Mutations of FOXL2 lead to disorders of ovarian function ranging from premature follicle depletion and ovarian failure to unregulated granulosa cell proliferation leading to tumor formation. Thus, FOXL2 is a key regulator of granulosa cell function and a master transcription factor in these cells. (Endocrinology 152: 1199-1208, 2011)
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