Journal
ENDOCRINOLOGY
Volume 151, Issue 9, Pages 4109-4115Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2010-0336
Keywords
-
Categories
Funding
- National Institutes of Health [DK068384, DK052989, DK083042, DK007247]
- American Diabetes Association
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK068384, T32DK007247, R01DK083042, R01DK052989, R01DK090320] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity. (Endocrinology 151: 4109-4115, 2010)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available