Journal
ENDOCRINOLOGY
Volume 149, Issue 11, Pages 5706-5712Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2008-0717
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Funding
- La Ligue Nationale Contre le Cancer
- Institut National de la Sante et de la Recherche Medicale
- Fondation Pour la Recherche Medicale
- Agence Nationale de la Recherche
- Association pour la Recherche sur le Cancer
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Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4(-/-) mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases. (Endocrinology 149: 5706-5712, 2008)
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