Journal
ENDOCRINOLOGY
Volume 149, Issue 3, Pages 950-954Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2007-1444
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Funding
- NIA NIH HHS [R01 AG20478, U01 AG020478] Funding Source: Medline
- NIDDK NIH HHS [P30 DK072476] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK072476] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG020478] Funding Source: NIH RePORTER
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Obesity, insulin resistance, type 2 diabetes mellitus, and aging are associated with impaired skeletal muscle oxidation capacity, reduced mitochondrial content, and lower rates of oxidative phosphorylation. Several studies have reported ultrastructural abnormalities in mitochondrial morphology and reductions in mitochondrial mass in insulin-resistant individuals. From lower organisms to rodents, mitochondrial membrane structure, function, and programmed cell death are regulated in part by the balance between the opposing forces of mitochondrial fusion and fission, suggesting they may also play an important role in human physiology.
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