Journal
ENDOCRINOLOGY
Volume 149, Issue 11, Pages 5500-5508Publisher
ENDOCRINE SOC
DOI: 10.1210/en.2008-0453
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Funding
- National Institute of Child Health
- Human Development/National Institutes of Health [R01 HD41469]
- National Institute of Neurological Disorders and Stroke
- National Research Service Award [F31 NS53253]
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A switch in the balance of estradiol feedback actions from negative to positive initiates the GnRH surge, triggering the LH surge that causes ovulation. Using an ovariectomized, estradiol-treated (OVX+E) mouse model that exhibits daily switches between negative in the morning and positive feedback in the evening, we investigated the roles of fast synaptic transmission in regulating GnRH neuron firing during negative and positive feedback. Targeted extracellular recordings were used to monitor activity of GnRH neurons from OVX+E and OVX mice in control solution or solution with antagonists to both ionotropic glutamate and gamma-aminobutyric acid receptors (blockade). Blockade had no effect on activity of OVX cells. In contrast, in OVX+E cells in the morning, blockade increased activity compared with control cells, whereas in the evening, blockade decreased activity.
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