Pulmonary Hypertension in Grave's Disease

Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery systolic pressure (PASP) >35 mm Fig or mean >30 mm Hg with exercise. Etiology is divided into primary or secondary causes. Common causes of secondary PAH are myocardial or valvular disease. obstructive or restrictive lung disease, sleep apnea, left ventricular dysfunction, pulmonary embolism, and connective tissue disorders. The association between PAH and hyperthyroidism was first reported in an autopsy case in 1980. We report here the case of a patient with reversible Pulmonary hypertension associated with Grave's disease managed only with medication. An association between Grave's disease and pulmonary hypertension was established here when other causes of pulmonary hypertension were ruled out and the patient had significant hemodynamic and symptomatic improvement after normalization of thyroid function.