Related references
Note: Only part of the references are listed.Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle
Jonas Moller Kristensen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)
Metformin Selectively Targets Tumor-Initiating Cells in ErbB2-Overexpressing Breast Cancer Models
Pei Zhu et al.
CANCER PREVENTION RESEARCH (2014)
Diabetes and cancer: 5 years into the recent controversy
Elena Badrick et al.
EUROPEAN JOURNAL OF CANCER (2014)
Type 2 diabetes as a redox disease
James D. Watson
LANCET (2014)
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Kivanc Birsoy et al.
NATURE (2014)
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
Andreas Janzer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Transport of biguanides by human organic cation transporter OCT2
Yoshihisa Sogame et al.
BIOMEDICINE & PHARMACOTHERAPY (2013)
A common novel splice variant of SLC22A1 (OCT1) is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia
Jacob Grinfeld et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer
Krushna C. Patra et al.
CANCER CELL (2013)
Association of metformin use with cancer incidence and mortality: A meta-analysis
Pengpeng Zhang et al.
CANCER EPIDEMIOLOGY (2013)
Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Sarah-Maria Fendt et al.
CANCER RESEARCH (2013)
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
Cecilia Marini et al.
CELL CYCLE (2013)
Glucose promotes breast cancer aggression and reduces metformin efficacy
Reema Wahdan-Alaswad et al.
CELL CYCLE (2013)
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert et al.
CELL METABOLISM (2013)
Metformin Temporal and Localized Effects on Gut Glucose Metabolism Assessed Using 18F-FDG PET in Mice
Michela Massollo et al.
JOURNAL OF NUCLEAR MEDICINE (2013)
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
Russell A. Miller et al.
NATURE (2013)
Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action
Shanmiao Gou et al.
PLOS ONE (2013)
Metformin and the Risk of Cancer Time-related biases in observational studies
Samy Suissa et al.
DIABETES CARE (2012)
Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials
R. J. Stevens et al.
DIABETOLOGIA (2012)
Obesity, type 2 diabetes, and cancer: the insulin and IGF connection
Dara Hope Cohen et al.
ENDOCRINE-RELATED CANCER (2012)
Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells
Barbara Salani et al.
FASEB JOURNAL (2012)
MicroRNA-143 (miR-143) Regulates Cancer Glycolysis via Targeting Hexokinase 2 Gene
Rong Fang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Comparative Analysis of Pharmacophore Screening Tools
Marijn P. A. Sanders et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Metformin: A Diabetes Drug for Cancer, or a Cancer Drug for Diabetics?
Matthew Martin et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang et al.
NATURE CELL BIOLOGY (2012)
Ablation of Both Organic Cation Transporter (Oct)1 and Oct2 Alters Metformin Pharmacokinetics but Has No Effect on Tissue Drug Exposure and Pharmacodynamics
J. William Higgins et al.
DRUG METABOLISM AND DISPOSITION (2012)
Human Organic Cation Transporter 1 Is Expressed in Lymphoma Cells and Increases Susceptibility to Irinotecan and Paclitaxel
Shivangi Gupta et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
The insulin and insulin-like growth factor receptor family in neoplasia: an update
Michael Pollak
NATURE REVIEWS CANCER (2012)
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Eric D. Segal et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Drug Transporters and Imatinib Treatment: Implications for Clinical Practice
Karel Eechoute et al.
CLINICAL CANCER RESEARCH (2011)
Clinical Pharmacokinetics of Metformin
Garry G. Graham et al.
CLINICAL PHARMACOKINETICS (2011)
Structure-Based Design of Potent Aromatase Inhibitors by High-Throughput Docking
Fabiana Caporuscio et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice
Shuanglian Li et al.
PHARMACEUTICAL RESEARCH (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC
M. P. Sajan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse
Daniel Da Silva et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis
Regan M. Memmott et al.
CANCER PREVENTION RESEARCH (2010)
Metformin: Taking away the candy for cancer?
Mathilde Jalving et al.
EUROPEAN JOURNAL OF CANCER (2010)
Energy restriction as an antitumor target
Hany A. Omar et al.
FUTURE ONCOLOGY (2010)
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Marc Foretz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
CoCoCo: a free suite of multiconformational chemical databases for high-throughput virtual screening purposes
Alberto Del Rio et al.
MOLECULAR BIOSYSTEMS (2010)
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
Ligong Chen et al.
PHARMACOGENETICS AND GENOMICS (2010)
Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
Heather A. Hirsch et al.
CANCER RESEARCH (2009)
Expression of Organic Cation Transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) Is Affected by Genetic Factors and Cholestasis in Human Liver
Anne T. Nies et al.
HEPATOLOGY (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
National Trends in Treatment of Type 2 Diabetes Mellitus, 1994-2007
G. Caleb Alexander et al.
ARCHIVES OF INTERNAL MEDICINE (2008)
Organic Cation Transporters and their Pharmacokinetic and Pharmacodynamic Consequences
Min-Koo Choi et al.
DRUG METABOLISM AND PHARMACOKINETICS (2008)
Metformin and glitazones: does similarity in biomolecular mechanism originate from tautomerism in these drugs?
Sandeep Sundriyal et al.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2008)
Polymorphism in human organic cation transporters and metformin action
Hiroshi Takane et al.
PHARMACOGENOMICS (2008)
The role of insulin receptors and IGF-I receptors in cancer and other diseases
Francesco Frasca et al.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2008)
Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
Masayo Aoki et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics
Y. Shu et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
Ryan J. O. Dowling et al.
CANCER RESEARCH (2007)
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
Mahvash Zakikhani et al.
CANCER RESEARCH (2006)
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
Ken Inoki et al.
CELL (2006)
Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
Rita Slaaby et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Organic cation transporters are determinants of oxaliplatin cytotoxicity
Shuzhong Zhang et al.
CANCER RESEARCH (2006)
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
A Natali et al.
DIABETOLOGIA (2006)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
SA Hawley et al.
CELL METABOLISM (2005)
Metformin and reduced risk of cancer in diabetic patients
JMM Evans et al.
BMJ-BRITISH MEDICAL JOURNAL (2005)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Hexokinase II: The integration of energy metabolism and control of apoptosis
JG Pastorino et al.
CURRENT MEDICINAL CHEMISTRY (2003)
Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes
P Iozzo et al.
DIABETES CARE (2003)
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
JE Wilson
JOURNAL OF EXPERIMENTAL BIOLOGY (2003)
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
MR Owen et al.
BIOCHEMICAL JOURNAL (2000)
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
MY El-Mir et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
