Journal
ENDOCRINE-RELATED CANCER
Volume 20, Issue 3, Pages R101-R111Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/ERC-13-0005
Keywords
pituitary; Wnt; adenoma; tumorigenesis; development
Categories
Funding
- Wellcome Trust
- MRC [MR/K500938/1] Funding Source: UKRI
- Medical Research Council [MR/K500938/1] Funding Source: researchfish
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Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.
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