Journal
ENDOCRINE-RELATED CANCER
Volume 21, Issue 1, Pages 51-61Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/ERC-13-0375
Keywords
prostate; neoplasia; molecular biology; biomarker; microarray
Categories
Funding
- Liga Portuguesa Contra o Cancro - Nucleo Regional do Norte, Research Center of Portuguese Oncology Institute - Porto [CI-IPOP 4-2008]
- European Community [FP7-HEALTH-F5-2009-241783]
- FCT-Fundacao para a Ciencia e a Tecnologia [SFRH/BD/70564/2010, SFRH/BD/71293/2010]
- Liga Portuguesa Contra o Cancro - Nucleo Regional do Norte
- Fundação para a Ciência e a Tecnologia [SFRH/BD/71293/2010, SFRH/BD/70564/2010] Funding Source: FCT
Ask authors/readers for more resources
Prostate cancer (PCa), a leading cause of cancer-related morbidity and mortality, arises through the acquisition of genetic and epigenetic alterations. Deregulation of histone methyltransferases (HMTs) or demethylases (HDMs) has been associated with PCa development and progression. However, the precise influence of altered HMTs or HDMs expression and respective histone marks in PCa onset and progression remains largely unknown. To clarify the role of HMTs and HDMs in prostate carcinogenesis, expression levels of 37HMTs and 20 HDMs were assessed in normal prostate and PCa tissue samples by RT-qPCR. SMYD3, SUV39H2, PRMT6, KDM5A, and KDM6A were upregulated, whereas KMT2A-E (MLL1-5) and KDM4B were downregulated in PCa, compared with normal prostate tissues. Remarkably, PRMT6 was the histone modifier that best discriminated normal from tumorous tissue samples. Interestingly, EZH2 and SMYD3 expression levels significantly correlated with less differentiated and more aggressive tumors. Remarkably, SMYD3 expression levels were of independent prognostic value for the prediction of disease-specific survival of PCa patients with clinically localized disease submitted to radical prostatectomy. We concluded that expression profiling of HMTs and HDMs, especially SMYD3, might be of clinical usefulness for the assessment of PCa patients and assist in pre-therapeutic decision-making.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available