Journal
ENDOCRINE-RELATED CANCER
Volume 16, Issue 4, Pages 1211-1218Publisher
BIOSCIENTIFICA LTD
DOI: 10.1677/ERC-09-0049
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- Finska lakaresallskapet
- Nona ja Kullervo Vareen saatio
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Phaeochromocytomas are uncommon tumours of adrenal or extra-adrenal chromaffin tissue. About 2-26% of these have been reported to metastasize, but, on histological criteria, it is virtually impossible to predict malignant behaviour of the tumour Using immunohistochemistry, we analysed the protein expression of SNAIL, a zinc-finger transcription factor, in a series of 50 phaeochromocytoma specimens from 42 patients. We found that SNAIL-expressing cells are frequent in metastatic primary tumours and their metastases, whereas in tumours without metastases, SNAIL expression is commonly absent We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma. Endocrine-Related Cancer (2009) 16 1211-1218
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