A PROTRACTED AND AGGRESSIVE VARIANT OF LYMPHOCYTIC HYPOPHYSITIS WITH MAMMILLARY BODY INVOLVEMENT AND COGNITIVE DYSFUNCTION

Objective: Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis. Methods: This is a case report. Results: Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum. Conclusion: This case broadens the clinical spectrum of lymphocytic hypophysitis.