Journal
ENDOCRINE JOURNAL
Volume 57, Issue 2, Pages 101-107Publisher
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.K09E-332
Keywords
GPR30; Membrane; GPCR; Estrogen; In vivo
Categories
Funding
- Ministry of Education, Science and Culture of Japan
- Takeda Science Foundation
- Novartis Foundation (Japan) for the Promotion of Science
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G protein-coupled receptor 30/G protein-coupled estrogen receptor-1 (GPR30/GPER-1) was reported as a novel membrane receptor for estrogen in 2005. However, the research on GPR30 has produced conflicting reports with regard to its intracellular localization, the tissue distribution of its expression, and some its functions. Recently, in addition to the finding of G-1, a GPR30 agonist, GPR30 KO mice have been produced in laboratories, and this has significantly increased the confidence in the data. In this review, the intrinsic appearance of GPR30 is approached based mainly on data obtained in vivo.
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