Journal
ENDOCRINE JOURNAL
Volume 57, Issue 6, Pages 467-475Publisher
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.K10E-095
Keywords
Sweet taste; Leptin; Endocannabinoids; Modulation; Energy homeostasis
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Funding
- Japan Society for the Promotion of Science [18109013, 1807704]
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The present study summarized recent findings on roles of leptin and endocannabinoids as modulators of the peripheral components of sweet taste. The positive effect of endocannabinoids on sweet sensitivity was opposed to that of leptin which suppresses sweet sensitivity. Leptin and endocannabinoids, therefore, not only regulate food intake via central nervous systems but also may modulate palatability of foods by altering peripheral sweet taste responses via their cognate receptors. Orexigenic and anorexigenic factors such as endocannnabinoids and leptin may affect energy homeostasis by regulating taste sensitivity.
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