Journal
ENDOCRINE JOURNAL
Volume 57, Issue 8, Pages 719-725Publisher
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.K10E-030
Keywords
IgG4; Pituitary; Hypopituitarism; Diabetes insipidus
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Funding
- Ministry of Health, Labor and Welfare of Japan
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IgG4-positive plasma cell infiltration into multiple organs or tissues, such as the pancreas and salivary Wands, associated with increased serum levels of IgG4 is a characteristic finding seen in IgG4-related disease Affected organs may appear tumorous as a result of chrome inflammatory processes accompanied with progressive fibrosis Recent cases of this disorder in which the pituitary gland was affected include cases of diffuse enlargement of the pituitary and/or its stalk associated with central diabetes insipidus and/or impaired anterior hormone production Here we report two such cases, as well as two additional previously undiagnosed cases found in our database. In order to make a correct diagnosis of pituitary lesion involvement with IgG4-related disease, the clinical background and concomitant disorders should be carefully taken into consideration and the measurement of serum levels of IgG4 seems to be useful
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