Journal
ENDOCRINE JOURNAL
Volume 56, Issue 1, Pages 1-7Publisher
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.K08E-099
Keywords
Stromal fibroblast; Estrogen signal; Aromatase; Breast cancer
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Funding
- Ministry of Education, Science, Sports and Culture, Japan
- Cancer Research from the Ministry of Health, Labor, and Welfare, Japan
- Smoking Research Foundation
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Stromal cells establish the microenvironment based on interaction with tumor cells, which is essential for cancer growth, invasion and metastasis. Fibroblasts are the primary component of stroma, and carcinoma-associated fibroblasts (CAFs) demonstrate tumor-promoting activities compared with normal Counterparts. In breast cancers, stromal fibroblasts adjacent to the tumor express aromatase, a key enzyme in the synthesis of estrogen, resulting in in situ estrogen production, and aromatase is a primary target of endocrine therapy. Thus, stromal fibroblasts demonstrate multiple functions in the genesis and progression of breast cancers. In this paper, we discuss the importance of tumor-stromal crosstalk in breast cancers, and describe our system to predict the efficacy of endocrine therapy and to analyze estrogen signals in individual breast cancers.
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