Journal
EMBO REPORTS
Volume 15, Issue 6, Pages 642-656Publisher
WILEY
DOI: 10.15252/embr.201438638
Keywords
cancer; Hippo pathway; regeneration; stem cell; YAP
Categories
Funding
- National institutes of Health [CA132809, EYO226116]
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The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription co-activators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.
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