Journal
EMBO REPORTS
Volume 15, Issue 3, Pages 231-243Publisher
WILEY
DOI: 10.1002/embr.201338225
Keywords
biogenesis; dynamics; mitophagy; ubiquitin; mitochondria
Categories
Funding
- Deutsche Forschungsgemeinschaft
- European Research Council [AdG 233078]
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Abstract Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and participates in maternal mtDNA inheritance. Under stress, mitochondrial dysfunction induces ubiquitin-dependent responses that involve mitochondrial proteome remodeling and culminate in organelle removal by mitophagy. In addition, many ubiquitin-dependent mechanisms have been shown to regulate innate immune responses and xenophagy. Here, we review the emerging roles of ubiquitin at mitochondria.
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