Journal
EMBO REPORTS
Volume 15, Issue 11, Pages 1202-1209Publisher
WILEY
DOI: 10.15252/embr.201438660
Keywords
Arabidopsis thaliana; heterotrimeric G protein; peptide hormone; RECEPTOR-LIKE PROTEIN KINASE 2; stem cell homeostasis
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Funding
- KAKENHI [221S0002, 23119517, 23012034, 24114001, 24114009, 24370024, 24657035, 24658032, 25119713, 25440134]
- NIBB [12-103]
- Grants-in-Aid for Scientific Research [23227001, 221S0002, 24657035, 25440134, 23012034, 24658032, 24114001, 26113713, 24114009] Funding Source: KAKEN
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Cell-to-cell communication is a fundamental mechanism for coordinating developmental and physiological events in multicellular organisms. Heterotrimeric G proteins are key molecules that transmit extracellular signals; similarly, CLAVATA signaling is a crucial regulator in plant development. Here, we show that Arabidopsis thaliana G mutants exhibit an enlarged stem cell region, which is similar to that of clavata mutants. Our genetic and cell biological analyses suggest that the G protein beta-subunit1 AGB1 and RPK2, one of the major CLV3 peptide hormone receptors, work synergistically in stem cell homeostasis through their physical interactions. We propose that AGB1 and RPK2 compose a signaling module to facilitate meristem development.
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