Journal
EMBO REPORTS
Volume 14, Issue 4, Pages 389-394Publisher
WILEY
DOI: 10.1038/embor.2013.15
Keywords
calcium; neurodegeneration; phosphorylation; receptors; tau
Categories
Funding
- Henry Smith Charity
- Alzheimer's Research UK
- Wellcome Trust
- Alzheimers Research UK [ART-EG2004A-1, ART-PhD2011-15, ART-TRF2011-2] Funding Source: researchfish
Ask authors/readers for more resources
Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphorylation of extracellular tau appears reduced in comparison with intracellular tau. We also find that AMPA-induced release of tau is calcium-dependent. Blocking pre-synaptic vesicle release by tetanus toxin and inhibiting neuronal activity with tetrodotoxin both significantly impair AMPA-mediated tau release. Tau secretion is therefore a regulatable process, dysregulation of which could lead to the spread of tau pathology in disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available