Journal
EMBO REPORTS
Volume 14, Issue 2, Pages 143-151Publisher
WILEY
DOI: 10.1038/embor.2012.220
Keywords
autophagy; non-autophagic roles; unconventional protein secretion; signalling; Atg protein function
Categories
Funding
- National Institutes of Health grant [GM 069373]
- Plan Nacional [BFU2008-00414]
- Consolider [CSD2009-00016]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca
- Grups de Recerca Emergents [SGR2009-1488]
- European Research Council [268692]
- ICREA Funding Source: Custom
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Autophagy and autophagy-related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin-like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non-autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non-autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.
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