Journal
EMBO REPORTS
Volume 13, Issue 6, Pages 528-538Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2012.61
Keywords
cancer; chromosomal instability; genomic instability; aneuploidy; intra-tumour heterogeneity
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Funding
- Cancer Research UK
- Medical Research Council
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Chromosomal instability (CIN)-which is a high rate of loss or gain of whole or parts of chromosomes-is a characteristic of most human cancers and a cause of tumour aneuploidy and intra-tumour heterogeneity. CIN is associated with poor patient outcome and drug resistance, which could be mediated by evolutionary adaptation fostered by intra-tumour heterogeneity. In this review, we discuss the clinical consequences of CIN and the challenges inherent to its measurement in tumour specimens. The relationship between CIN and prognosis supports assessment of CIN status in the clinical setting and suggests that stratifying tumours according to levels of CIN could facilitate clinical risk assessment.
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