Journal
EMBO REPORTS
Volume 14, Issue 3, Pages 242-251Publisher
WILEY
DOI: 10.1038/embor.2013.5
Keywords
adipocytes; Akt; insulin; liver; mTOR
Categories
Funding
- National Science Foundation [DGE-1144152]
- National Institutes of Health [R01-CA122617, P01-CA120964]
- Department of Defense [TS093033, TS110065]
- Sanofi Innovation Award
- American Diabetes Association
- Ellison Medical Foundation
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The mechanistic target of rapamycin is a protein kinase that, as part of the mechanistic target of rapamycin complex 1 (mTORC1), senses both local nutrients and, through insulin signalling, systemic nutrients to control a myriad of cellular processes. Although roles for mTORC1 in promoting protein synthesis and inhibiting autophagy in response to nutrients have been well established, it is emerging as a central regulator of lipid homeostasis. Here, we discuss the growing genetic and pharmacological evidence demonstrating the functional importance of its signalling in controlling mammalian lipid metabolism, including lipid synthesis, oxidation, transport, storage and lipolysis, as well as adipocyte differentiation and function. Defining the role of mTORC1 signalling in these metabolic processes is crucial to understanding the pathophysiology of obesity and its relationship-to complex diseases, including diabetes and cancer.
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