Journal
EMBO REPORTS
Volume 13, Issue 6, Pages 539-546Publisher
WILEY
DOI: 10.1038/embor.2012.54
Keywords
cohesin; aneuploidy; chromosome segregation; meiosis; oocytes
Categories
Funding
- Deutsche Forschungsgemeinschaft [SPP1384]
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The trend of women to become pregnant when older than in previous generations poses a paramount medical problem, for oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Recent data strongly suggest that as oocyte age increases sister chromatid cohesion is weakened or lost. Cohesin deterioration seems to contribute significantly to age-dependent aneuploidy, as discussed in this review.
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