Journal
EMBO REPORTS
Volume 13, Issue 9, Pages 835-839Publisher
WILEY
DOI: 10.1038/embor.2012.106
Keywords
ribosome; L11; ppGpp; alarmone; signalling
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Funding
- Estonian Science Foundation [6768, 7616, 9012, DoRa 6]
- European Regional Development Fund through the Center of Excellence in Chemical Biology
- Swedish Institute
- European Research Council
- Foundation for Strategic Research
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Human Frontier Science Program cross-disciplinary fellowship
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During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regulation of an enzyme by its product. Positive allosteric regulation therefore constitutes a new mechanism of enzyme activation. By integrating the output of individual RelA molecules and ppGpp degradation pathways, this regulatory circuit contributes to a fast and coordinated transition to stringency.
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