Journal
EMBO REPORTS
Volume 13, Issue 5, Pages 440-447Publisher
WILEY
DOI: 10.1038/embor.2012.32
Keywords
antibiotics; asthma; gut; microbiota
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- CIHR Emerging Team
- Genome BC
- AllerGen NCE
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Allergic asthma rates have increased steadily in developed countries, arguing for an environmental aetiology. To assess the influence of gut microbiota on experimental murine allergic asthma, we treated neonatal mice with clinical doses of two widely used antibiotics-streptomycin and vancomycin-and evaluated resulting shifts in resident flora and subsequent susceptibility to allergic asthma. Streptomycin treatment had little effect on the microbiota and on disease, whereas vancomycin reduced microbial diversity, shifted the composition of the bacterial population and enhanced disease severity. Neither antibiotic had a significant effect when administered to adult mice. Consistent with the 'hygiene hypothesis', our data support a neonatal, microbiota-driven, specific increase in susceptibility to experimental murine allergic asthma.
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