Journal
EMBO REPORTS
Volume 13, Issue 5, Pages 431-439Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2012.29
Keywords
angiogenesis; endothelial-mesenchymal transition; pancreatic cancer; Slug; Tie1
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Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Association pour la Recherche sur le Cancer (ARC)
- Ligue Nationale Contre le Cancer ('Equipe Labellisee')
- Ligue Nationale Contre le Cancer
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Endothelial-mesenchymal transition (EndMT) has a significant role in embryonic heart formation and in various pathologies. However, the molecular mechanisms that regulate EndMT induction remain to be elucidated. We show that suppression of receptor tyrosine kinase Tie1 but not Tie2 induces human endothelial cells to undergo EndMT and that Slug deficiency reverts this process. We find that Erk1/2, Erk5 and Akt cascades control Slug promoter activity induced by Tie1 deficiency. Interestingly, EndMT is present in human pancreatic tumour. We propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours.
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