Journal
EMBO REPORTS
Volume 12, Issue 11, Pages 1144-1152Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2011.165
Keywords
cargo receptor; p24; Wnt secretion
Categories
Funding
- Forschungskredit Zurich
- European Molecular Biology Organization
- Swiss National Science Foundation
- Kanton of Zurich
- ERC
Ask authors/readers for more resources
Wnt proteins are secreted, lipid-modified glycoproteins that control animal development and adult tissue homeostasis. Secretion of Wnt proteins is at least partly regulated by a dedicated machinery. Here, we report a genome-wide RNA interference screen for genes involved in the secretion of Wingless (Wg), a Drosophila Wnt. We identify three new genes required for Wg secretion. Of these, Emp24 and Eclair are required for proper export of Wg from the endoplasmic reticulum (ER). We propose that Emp24 and Eca act as specific cargo receptors for Wg to concentrate it in forming vesicles at sites of ER export.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available