Journal
EMBO REPORTS
Volume 12, Issue 7, Pages 720-726Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2011.88
Keywords
pluripotency; somatic cell reprogramming; E-cadherin; OCT4
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Funding
- Bundersministerium fur Bildung und Forschung (BMBF) [01GN0941]
- European Commission [FP6-021407]
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We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully reprogrammed cells were exclusively observed in the E-cadherinpositive cell population and could not be obtained in the absence of E-cadherin. Moreover, reprogrammed cells could be established by viral E-cadherin in the absence of exogenous OCT4. Thus, reprogramming requires spatial cues that cross-talk with essential transcription factors. The cell-adhesion molecule E-cadherin has important functions in pluripotency and reprogramming.
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