Journal
EMBO REPORTS
Volume 13, Issue 2, Pages 113-120Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2011.248
Keywords
IL-17; T(H)17; autoimmune; mucosal host defence; plasticity
Categories
Funding
- Medical Research Council UK [U117512792]
- European Research Council [232782]
- Medical Research Council [MC_U117512792] Funding Source: researchfish
- MRC [MC_U117512792] Funding Source: UKRI
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Interleukin-17 (IL-17)-mediated immune responses play a crucial role in the mucosal host defence against microbial and fungal pathogens. However, the chronic activation of IL-17-producing T helper cells can cause autoimmune disease. In addition, recent studies have highlighted key roles of innate cell-mediated IL-17 responses in various inflammatory settings. Besides inflammation, there have also been intriguing findings regarding the involvement of IL-17 responses in the pathogenesis of cardiovascular diseases and tumour formation. Here, we discuss the latest discoveries in regulation and function of innate and adaptive IL-17-producing cells.
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