Journal
EMBO REPORTS
Volume 12, Issue 2, Pages 129-135Publisher
WILEY
DOI: 10.1038/embor.2010.207
Keywords
SUMO; TANK; TLR signalling; NF-kappa B; transcription
Categories
Funding
- Deutscher Akademischer Austausch Dienst,
- Humboldt Foundation
- Deutsche Forschungsgemeinschaft
- Excellence Cluster Cardio-Pulmonary System
- Landes-Offensive zur Entwicklung Wissenschaftlich-okonomischer Exzellenz program
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Adaptor proteins allow temporal and spatial coordination of signalling. In this study, we show SUMOylation of the adaptor protein TANK and its interacting kinase TANK-binding kinase 1 (TBK1). Modification of TANK by the small ubiquitin-related modifier (SUMO) at the evolutionarily conserved Lys 282 is triggered by the kinase activities of I kappa B kinase epsilon (IKK epsilon) and TBK1. Stimulation of TLR7 leads to inducible SUMOylation of TANK, which in turn weakens the interaction with IKK epsilon and thus relieves the negative function of TANK on signal propagation. Reconstitution experiments show that an absence of TANK SUMOylation impairs inducible expression of distinct TLR7-dependent target genes, providing a molecular mechanism that allows the control of TANK function.
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