Journal
EMBO REPORTS
Volume 12, Issue 3, Pages 252-258Publisher
WILEY-BLACKWELL
DOI: 10.1038/embor.2011.4
Keywords
Salmonella; hormones; haemolysin; micA; cpx
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Funding
- Medical Research Council
- Wellcome Trust
- MRC [G0501449, G0801212] Funding Source: UKRI
- Medical Research Council [G0501449, G0801212] Funding Source: researchfish
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Salmonella enterica serovar Typhi ( S. typhi) causes typhoid fever. We show that exposure of S. typhi to neuroendocrine stress hormones results in haemolysis, which is associated with the release of haemolysin E in membrane vesicles. This effect is attributed to increased expression of the small RNA micA and RNA chaperone Hfq, with concomitant downregulation of outer membrane protein A. Deletion of micA or the two-component signal-transduction system, CpxAR, abolishes the phenotype. The hormone response is inhibited by the beta-blocker propranolol. We provide mechanistic insights into the basis of neuroendocrine hormone-mediated haemolysis by S. typhi, increasing our understanding of inter-kingdom signalling.
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