Journal
EMBO REPORTS
Volume 12, Issue 12, Pages 1265-1272Publisher
WILEY
DOI: 10.1038/embor.2011.212
Keywords
Wnt secretion; p24 proteins; protein transporting; signalling
Categories
Funding
- DKFZ Light Microscopy Facility
- European Commission
- Deutsche Forschungsgemeinschaft [FOR1036]
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During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocytic pathway. Here we identify several Drosophila p24 proteins that are required for Wnt signalling. We demonstrate that one of these p24 proteins, namely Opossum, shuttles in the early secretory pathway, and that the Drosophila Wnt proteins are retained in the absence of p24 proteins. Our results indicate that Wnt secretion relies on a specialized anterograde secretion route with p24 proteins functioning as conserved cargo receptors.
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