Journal
EMBO REPORTS
Volume 11, Issue 11, Pages 834-840Publisher
WILEY
DOI: 10.1038/embor.2010.160
Keywords
diabetes; insulin signalling; MAPK; metabolism; obesity
Categories
Funding
- European Foundation for the Study of Diabetes (EFSD)
- Swiss National Foundation (SNF) [PP00A-114856]
- ETH Independent Investigators' Research Award (ETHIIRA)
- Swiss Society for Endocrinology and Diabetology (SSED)
- EMBO
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Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intra-cellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but inappropriate MAPK signalling contributes to the development of several interdependent pathological traits, collectively known as metabolic syndrome. Metabolic syndrome leads to life-threatening clinical consequences, such as type 2 diabetes. This Review provides an overview of the MAPK-signalling mechanisms that underly basic cellular metabolism, discussing their link to disease.
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