Journal
EMBO REPORTS
Volume 11, Issue 7, Pages 541-547Publisher
WILEY
DOI: 10.1038/embor.2010.75
Keywords
GCN5; PCAF; SAGA; LUZP1; snRNA biogenesis
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Funding
- INSERM-Region Alsace
- Association pour la Recherche sur le Cancer
- Agence Nationale de la Recherche [ANR-09-BLAN-0266]
- European Union [LSHG-CT-2007-037445]
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0266] Funding Source: Agence Nationale de la Recherche (ANR)
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The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.
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