Journal
EMBO REPORTS
Volume 12, Issue 1, Pages 43-49Publisher
WILEY
DOI: 10.1038/embor.2010.185
Keywords
beta-catenin; PTK7; Wnt; Xenopus
Categories
Funding
- Centre National de la Recherche Scientifique
- Inserm
- Institut Paoli-Calmettes
- Association pour la Recherche contre le Cancer
- Agence Nationale de la Recherche
- Ligue Nationale Contre le Cancer
- Fondation de France
- European Consortium for Anticancer Antibody Development and Infrastrutures en Biologie Sante et Agronomie (Marseille Proteomic Platform)
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The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog embryonic development. In this study, we report that PTK7 interacts with beta-catenin in a yeast two-hybrid assay and mammalian cells. PTK7-deficient cells exhibit weakened beta-catenin/T-cell factor transcriptional activity on Wnt3a stimulation. Furthermore, Xenopus PTK7 is required for the formation of Spemann's organizer and for Siamois promoter activation, events that require beta-catenin transcriptional activity. Using epistatic assays, we demonstrate that PTK7 functions upstream from glycogen synthase kinase 3. Taken together, our data reveal a new and conserved role for PTK7 in the Wnt canonical signalling pathway.
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