Journal
EMBO REPORTS
Volume 12, Issue 1, Pages 71-76Publisher
WILEY
DOI: 10.1038/embor.2010.189
Keywords
bacterial infection; RNA; phagocytosis; signal transduction
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Funding
- Bundesministerium fur Bildung und Forschung (BMBF) [01 EO 0803]
- Deutsche Forschungsgemeinschaft [He 3127/2-3, 3-1]
- National Institutes of Health [ROI AI052455-06A1]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI052455] Funding Source: NIH RePORTER
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Group B streptococcus (GBS) is a leading cause of both neonatal sepsis and meningitis, two diseases that are characterized by inflammation. However, the manner in which GBS organisms are recognized by monocytes and macrophages is poorly understood. In this study, we report that the recognition of GBS and other Gram-positive bacteria by macrophages and monocytes relies on bacterial single-stranded RNA (ssRNA). ssRNA interacts with a signalling complex, which comprises the Toll-like receptor adaptors MyD88 and UNC-93B, but not the established MyD88-dependent ssRNA sensors. The role of ssRNA in the recognition of Gram-positive bacteria-leading to the induction of inflammatory cytokines-has potential implications for sepsis pathogenesis, diagnosis and treatment.
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