Journal
EMBO REPORTS
Volume 11, Issue 1, Pages 52-58Publisher
WILEY
DOI: 10.1038/embor.2009.254
Keywords
epigenetic silencing; NoRC; non-coding RNA; rDNA; spacer promoter
Categories
Funding
- Deutsche Forschungsgemeinschaft
- European Union Network 'Epigenome'
- Fonds der Chemischen Industrie
- Federation of European Biochemical Societies
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Epigenetic silencing of a fraction of ribosomal DNA (rDNA) requires association of the nucleolar chromatin-remodelling complex NoRC to 150-250 nucleotide RNAs (pRNA) that originate from an RNA polymerase I promoter located in the intergenic spacer separating rDNA repeats. Here, we show that NoRC-associated pRNA is transcribed from a sub-fraction of hypomethylated rRNA genes during mid S phase, acting in trans to inherit DNA methylation and transcriptional repression of late-replicating silent rDNA copies. The results reveal variability between individual rDNA clusters with distinct functional consequences.
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