Journal
EMBO REPORTS
Volume 10, Issue 10, Pages 1103-1110Publisher
WILEY
DOI: 10.1038/embor.2009.203
Keywords
natural killer cell; innate immunity; memory; IL-22; cytokine
Categories
Funding
- Howard Hughes Medical Institute
- National Institutes of Health (NIH) [AI34385, AI33903, AI51345, AI57160, AR48335]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [T32HD043010] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U54AI057160, R37AI034385, R01AI033903, R01AI051345, R01AI034385] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P30AR048335] Funding Source: NIH RePORTER
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Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells and producing immunoregulatory cytokines. Herein, we discuss recent studies that indicate that NK cells span the conventional boundaries between innate and adaptive immunity. For example, it was recently discovered that NK cells have the capacity for memory-like responses, a property that was previously thought to be limited to adaptive immunity. NK cells have also been identified in multiple tissues, and a subset of cells that specialize in the production of the T(H)17 cytokine IL-22, NK-22s, was recently described in mucosal-associated lymphoid tissue. Finally, we review work that shows that NK cells develop at sites that were traditionally thought to be occupied only by adaptive immune cells, including the thymus and lymph nodes.
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