Journal
EMBO REPORTS
Volume 9, Issue 11, Pages 1094-1100Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2008.191
Keywords
ADP-ribose; chromatin; DNA repair; NaD(+) metabolism; transcription
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Funding
- CNRS
- University Strasbourg I
- Electricite de France and Ligue contre le cancer (comite du Bas-Rhin)
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Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid-like molecule poly(ADP-ribose) (PAR) has been known for 40 years, understanding its biological functions-originally thought to be only the regulation of chromatin superstructure when DNA is broken-is still the subject of intense research. Here, we review the mechanisms controlling the biosynthesis of this complex macromolecule and some of its main biological functions, with an emphasis on the most recent advances and hypotheses that have developed in this rapidly growing field.
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