Journal
EMBO REPORTS
Volume 9, Issue 3, Pages 280-286Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2008.10
Keywords
NEDD8; proteomics; proteasome; ribosomal proteins
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BBS/B/11974/2] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/B/11974/2] Funding Source: Medline
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Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.
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